Transmigración de canino mandibular: etiología, manejo quirúrgico y consideraciones especiales / Mandibular canine transmigration: etiology, surgical management and special considerations

En raras ocasiones, el canino mandibular derecho o izquierdo se coloca en el lado opuesto al habitual. Esta perturbación se define como la transmigración. Existen diversas teorías de su etiología, así como factores que la condicionan. La transmigración mandibular es un término que no está descrito en la literatura contemporánea y son pocos los casos reportados a nivel mundial. Presentamos un caso de trasmigración de canino mandibular derecho, posicionado por debajo del agujero mentoniano de lado izquierdo, cerca del borde basal mandibular, el cual se extrajo bajo anestesia general. Presentamos la etiología, técnica quirúrgica y consideraciones especiales en casos de trasmigración de canino mandibular (AU)

In rare occasions right or left mandibular canine is positionated at opposed side of habitual. This disturbance is defined as transmigration. There exist diverse theories about its etiology as well as conditioning factors. Mandibular transmigration is a non described term in modern literature and there are only a few reported cases at world level. We present one case of right canine transmigration positionated intimately below of left side mentonian hole near of mandibular basal edge which it was extracted under general anesthesia. We present also the etiology, surgical technique and special considerations of mandibular canine transmigration cases (AU)

Role of carboxypeptidase E in promoting the migration of lymphocytes through vascular endothelial cells / 中华微生物学和免疫学杂志

Objective To study the mechanism of carboxypeptidase E ( CPE ) in promoting the migration of lymphocytes and their subsets through vascular endothelial cells. Methods CRISPR/Cas9 technology was used to prepare cpe gene-knockout MS1 (Cpe-/-MS1) cells. Adhesion ability of lymphocytes to MS1 and Cpe-/-MS1 cells was analyzed with adhesion assay. Expression of adhesion molecules on these cells were detected by RT-PCR and flow cytometry. Transwell model was used to compare the difference in the transmigration of lymphocytes and their subsets through MS1 and Cpe-/-MS1 cells. Results Cpe-/-MS1 cells were successfully obtained. Under the stimulation of TNF-α, the adhesion ability of lymphocytes to MS1 cells was much better than that of Cpe-/-MS1 cells. Moreover, adhesion molecules expressed on MS1 cells were significantly more than those on Cpe-/-MS1 cells. The percentages of lymphocytes and their sub-sets that transmigrated through MS1 cells were significantly higher than those through Cpe-/-MS1 cells. Con-clusion CPE involved in the adhesion of lymphocytes to vascular endothelial cells and the transmigration of them through vascular endothelial cells, which was of great significance for understanding the migration of lymphocytes across vascular endothelial cells to peripheral lymph nodes.

Food consumption and dietary diversity of women in transmigrant area Buol, Central Sulawesi and original location Demak, Central Java, Indonesia

@#Introduction: The transmigration scheme of the Indonesian government was aimed at easing overpopulation in Java by moving people to less populated areas. This study investigated food consumption and dietary diversity of women from the original location and transmigration rice farming areas. Methods: Food intake using a single 24-hour dietary recall was determined among women of reproductive age in Demak, Central Java (original location) and Buol, Central Sulawesi (transmigrant area). Food taboos were investigated using focus group discussions (FGDs). Dietary diversity and its score were obtained from 387 and 121 women in Demak and Buol, respectively, while 38 women from both areas participated in four FGDs on food taboos. Results: On average, women from both study areas had low dietary diversity scores, especially among lactation mothers. Rice, swamp cabbage, spinach and tempeh were popular in both areas. Fruits and vegetables from own cultivation or collected as wild foods were consumed in Buol, while women in Demak consumed comparatively more purchased foods (fruits and vegetables, legumes, meat and fish). Fewer types of food was avoided during pregnancy and lactation in Buol. Conclusion: While some food intake behaviour was similar in both study areas, differences were observed as influenced by economic and environment factors. Food intake of Demak women was influenced by household purchasing power, while Buol women depended on own grown food and gatherings from nearby forest. As dietary diversity scores in both areas was low, nutrition interventions are suggested to improve maternal food intake during pregnancy and lactation.

Ectopic Eruption of a Transmigrated Mandibular Canine: A Rare Case Report.

Migration of teeth, both physiological as well as pathological, is a well-documented phenomenon. Transmigration, on the other hand, is a rare phenomenon where a tooth crosses the midline and migrates to the opposite side without any pathological influence. An impacted tooth especially canines migrate to a location some distance away but do not usually cross the midline. Even so, the tooth remains impacted. Here is a unique case of transmigration of a left mandibular canine, which has erupted labial to its counterpart on the right mandibular arch. Transmigration of the mandibular canine is a rare phenomenon. Even rare is an eruption of this transmigrated canine into the opposite arch where it can be mistaken as a supernumerary tooth.

Transmigration of the Mandibular Canine: A Report of Two Rare Cases.

When the tooth, instead of erupting in its normal position, remains impacted and crosses midline and is seen on the opposite side of the jaw, it is termed as Transmigration; e.g., right side tooth is seen on the left side and vice-versa. This phenomenon occurs without any pathology intervening cause. Canines are commonly seen unerupted and remain impacted, but rarely seen crossing the midline and migrating to the opposite side. They are usually symptomless. Here, we present two such rare cases of transmigration of the mandibular canine, one from the right side to the left side and appearing piercing the lower border of the mandible and producing a hard bulge on the left side of the lower jaw, but without any pain. The other case is of transmigration of mandibular left canine toward the right side well below the inferior alveolar canal beyond mental foramen facing toward posterior region of the mandible and causing pain symptoms in the jaw due to its close proximity to inferior alveolar canal. It is very essential to have panoramic radiograph to detect such abnormalities at an early stage to plan treatment and avoid future complications. Cone beam computed tomography images also play an important role.

Unusual transmigration of canines: report of two cases in a family

Introduction: Transmigration is pre-eruptive migration of tooth across the midline. The etiology of this rare anomaly is unknown. Transmigration is largely related to mandibular canines. Although maxillary canine transmigrations are found in the literature, they are still a rare entity. Objective: The aim of the present paper is to report two cases of unusual transmigrations of canines in two immediate members of a family and to report the first case of simultaneous transmigration of maxillary and mandibular canines in an Indian adolescent. Case report: A rare case of simultaneous transmigration of maxillary and mandibular canine in Indian adolescent along with bilateral transmigration of mandibular canines in her father is described here. Conclusion: Transmigration of canines in two immediate members of family needs to be further studied for familial occurrence of transmigration.

A rare case of compound odontomas in anterior mandible.

Odontomas are non-aggressive hamartomatous developmental malformations or lesions of odontogenic origin consist of enamel, dentin, cementum and pulpal tissue. Odontomas are classified in to compound and complex. Maxillary anterior region is the most frequent site for the occurrence of compound odontomas. Intraosseous migration of unerupted teeth is a rare natural condition wherein the tooth usually shows impaction due to many pathological conditions and it occurs more in mandible involves primarily the second premolars or the canine. Among these many pathological conditions odontomas are the one of them but rarest is compound odontomas in anterior mandible. Although there are many studies and statistical data on lesions available, diagnosis should not be restricted by epidemiological characteristics. Instead it is important to account all clinical, radiographic, and pathologic signs and symptoms as well as differential diagnosis for definitive diagnosis. Additionally, it is clear that lesions often behave in an unforeseen or unusual ways. Thus, we are concluding that considering the literature, the compound odontomas their incidence is rare and unusual in anterior region of mandible. We are presenting a case with rare incidence of compound odontomas in anterior region of mandible with transmigration of impacted canine.

First case of bimaxillary transmigration of impactedcanines: report of a rare case and review of literature / Primeiro caso de transmigração bimaxilar de caninosimpactados: relato de um caso raro e revisão da literatura

Objective: To present a rare case of bimaxillary transmigration of impacted canines. Discussion: Preeruptivemigration of a tooth across the midline is termed transmigration. Transmigration typically affectsthe mandibular canines, but occurs rarely in maxillary canines as well. Transmigration of mandibular canineacross the midline is rare. An even less common finding is transmigration of maxillary canine acrossthe midline. The least common finding is bimaxillary occurrence of canines transmigration. Conclusion:Migration of both upper and lower canine teeth on the same side across the midline is called bimaxillarytransmigration, which is a very rare phenomenon of oral and maxillofacial complex, often undetected inroutine dental examination, neither clinical, nor periapical radiographic examination.

Objetivo: Apresentar um caso raro de transmigração bimaxilar de caninos impactados. Discussão: A migraçãopré-eruptiva de um dente através da linha média é denominado transmigração. A transmigraçãotipicamente afeta os caninos inferiores, mas pode ocorrer raramente em caninos superiores também. Transmigraçãode canino inferior através da linha média é rara, porém um achado ainda menos comum é a ocorrênciade transmigração bimaxilar de caninos. Conclusão: A migração de caninos superiores e inferiores nomesmo lado e cruzando a linha média é chamada de transmigração bimaxilar, um fenômeno raro de sistema bucal e maxilofacial, frequentemente diagnosticado em exame clínico odontológico de rotina ou exame radiográficoperiapical.

Bilateral transmigration of impacted mandibular canines: report of two cases and review / Transmigração bilateral de caninos inclusos mandibulares: relato de dois casos e revisão

Objective: To present and discuss a rare case of transmigration of bilateral mandibular canines. To review the literature and to discuss treatment. Discussion: Transmigration of the canine tooth is an uncommonphenomenon, often undetected in routine dental examinations. The less common finding is type 5 (the canine is positioned vertically in the midline with the long axis of the tooth crossing the midline)and the least common phenomenon is bilateral occurrence of type 5. There is no known etiology for its occurrence. Conclusion: Transmigration of mandibular canines across the midline is a rare condition. An even less common finding is bilateral transmigration of canines across the midline.

Objetivo: Apresentar e discutir um caso raro de transmigração bilateral de caninos mandibulares; revisar a literatura; e discutir tratamentos. Discussão: A transmigração de caninos é um fenômeno incomum que frequentemente não édetectado no exame clínico de rotina. O achado menos comum é o tipo 5 (canino posicionado verticalmente com o seulongo eixo cruzando a linha média) e o fenômeno menos comum é a ocorrência bilateral do tipo 5 de transmigração. A sua etiologia é desconhecida. Conclusão: A transmigração de caninos mandibulares cruzando a linha média é rara e um achado ainda menos comum é a transmigração bilateral de caninos cruzando a linha média.

Human bone morphogenetic protein 3(hBMP3) inhibits growth of human osteosarcoma cells MG63 and U2OS / 基础医学与临床

Objective The biological effects of BMP3 on osteosarcoma were investigated by treating human osteosarcoma cell lines MG63,and U2OS with human BMP3(hBMP3).Methods Osteosarcoma cells in experimental groups were respectively treated with AdBMP-3 and rhBMP3-CM,control groups with AdGFP and rGFP-CM,the blank group with neither.Their ability of proliferation,apoptosis,transmigration and differentiation were respectively detected by trypan blue exclusion test,terminal deoynucleotidyl transferase mediated dUTP nick end labeling(TUNEL) and acridine orange-ethidium bromide fluorescent stain(AO/EB),transwell-room and alkaline phosphatase(ALP) activity reagent kit.Results(1) All the indexes detected were not significantly different between two control groups.(2) Compared with control groups,the cell survival rate showed a significant decrease in experimental groups.(3) The apoptosis indexes increased.(4)The number of trans-membrane cell decreased.(5)The activity of alkaline phosphatase increased after treatment with AdBMP3 and rhBMP-3 for 3 days in MG63,5 days in U2OS.Conclusion hBMP3 inhibit osteosarcoma cells growth and promote bone formation.

Effect of Low Molecular Weight Agarieus Blazei Murill Polysach-aride on Colon Carcinoma HT-29 Cell-endothelium migration and Adhesion / 医学研究杂志

Objective To investigate the effects of low molecular weight polysaccharide lsolated from agaricus blazei murill (LMPAB) on adhesion and migration of tumor cell and HUVECs. Methods HT-29 cell and HUVECs proliferation was analyzed by MTT.Adhesion and transmigration monolayer HUVECs ability of HT-29 was examined by spectrophotometry and transwell chambers.Results LMPAB showed no cytotoxic effect on HT-29 cells and HUVECs. LMPAB could significantly decrease HT-29 adhesion and transmigration through HUVECs.Conclusion LMPAB exerts the anti-tumor metastasis activity via inhibition of tumor cell adhesion and migration HUVECs.

Estudo da transmigração bacteriana na apendicite experimental em coelhos

The present study aims to evaluate the occurrence of the bacterial transmigration in induced ezxperimental appendicitis in rabbitis through complete oclusion of the vermiform appendix. 24 New Zealand white rabbits with a body weight ranging from 2500 to 3000 grams were used. They were divided into 2 groups. The animals from group I were submitted to a median laparotomy and fragments from the spleen, left kidney, right lung, abdominal limphonode, light content from the vermiform appendix and blood from the portal vein were withdrawn for culture. The animals from group 2 were submitted to median laparotomy and complete occlusion of the vermiform appendix in order to induce appendicitis and, after 24 hours, material was collected following the steps of group 1. It was not observed an increase in bacteria in the samples analysed in the Control Group Group 1). The increase of Escherichia coli was observed in all the animals from the Experiment Group (Group 2). The bacterial transmigration occured after 24-hour observation in rabbits with experimental appendicitis.

Introdução: A queda extrínseca dos mecanismos de defesa de um hospedeiro é vista classicamente como uma infecção, que resulta na aquisição de um tecido normal, de um novo microorganismo, cuja virulência é fundamental para a sua patogenia.Na década de 50, estudos comprovaram que bactérias e endotoxinas podem ultrapassar a barreira intestinal e atingir a circulação, demonstrando ainda, que a flora intestinal representa uma importante fonte para o desenvolvimento da infecção sistêmica. Objetivo: o presente estudo visa avaliar a ocorrência de transmigração bacteriana em apendicite experimental induzida em coelhos, mediante a oclusão completa do apêndice vermiforme. Métodos: foram utilizados 24 coelhos brancos, da linhagem Nova Zelândia, com peso corporal variando de 2500 a 3000 gramas, sendo então divididos em 2 grupos. Os animais do Grupo I foram submetidos a laparotomia mediana e retirada de fragmentos do baço, rim esquerdo, pulmão direito, linfonodo abdominal, conteúdo da luz do apêndice vermiforme e sangue da veia porta para cultura. Os animais do Grupo II foram submetidos a laparotomia mediana e oclusão completa do apêndice vermiforme para a indução de apendicite e, após 24 horas, realizada a coleta do material nos moldes do Grupo I. Resultados: No Grupo controle (Grupo I), não se observou o crescimento de bactérias nas amostras analisadas. No Grupo experimento (Grupo II), observou-se o crescimento de Escherichia coli em todos os animais. Conclusão: Ocorreu transmigração bacteriana após 24 horas de observação em coelhos com apendicite experimental.